Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.61 |
| ▸ | KIT | P10721 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887126 | 0.84 | CYP3A4 (0.70) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL1887276 | 0.76 | CYP3A4 (1.00) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL1885683 | 0.74 | CYP2C9 (0.71) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL1888026 | 0.74 | CYP3A4 (0.86) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL1885768 | 0.73 | CYP3A4 (0.79) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL1887139 | 0.73 | CYP3A4 (0.79) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL1885261 | 0.73 | CYP3A4 (0.79) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL1885003 | 0.73 | CYP3A4 (0.79) | CYP3A4CYP2C9KITKDRFLT3 | |
| Plx-5622 SCHEMBL1886955 | 0.72 | CYP3A4 (1.00) | CYP3A4CYP2C9KITKDRFLT3 | |
| Plx-5622 SCHEMBL29372414 | 0.72 | CYP3A4 (1.00) | CYP3A4CYP2C9KITKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096593-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140045840-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2014-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045840-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | KIT, FLT3, BRAF | CYP3A4 3717/4885CYP2C9 3884/4885KIT 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.