Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517050 | 1.00 | HSD17B10 (0.52) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL126194 | 1.00 | HSD17B10 (0.52) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL21547377 | 1.00 | HSD17B10 (0.52) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL12344760 | 1.00 | HSD17B10 (0.52) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL16645332 | 1.00 | HSD17B10 (0.52) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| Bromide SCHEMBL2542868 | 0.98 | HSD17B10 (0.50) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1375642 | 0.98 | HSD17B10 (0.50) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL16645317 | 0.93 | HSD17B10 (0.47) | HSD17B10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL29299530 | 0.91 | HSD17B10 (0.45) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20686921 | 0.91 | HSD17B10 (0.45) | HSD17B10MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648176-B2 | Engineered proteins with high affinity for DOTA chelates | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-02-11 | — | — | US | disclosed |