Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 19/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2633035 | 0.94 | AR (0.63) | ARNR3C1HDAC1 | |
| SCHEMBL13973946 | 0.90 | AR (0.51) | ARNR3C1HDAC1HDAC3HDAC2 | |
| SCHEMBL10072559 | 0.90 | AR (0.59) | ARNR3C1HDAC1 | |
| SCHEMBL30184873 | 0.87 | AR (0.76) | ARNR3C1HDAC1 | |
| SCHEMBL547082 | 0.87 | AR (0.76) | ARNR3C1HDAC1 | |
| SCHEMBL29508770 | 0.85 | AR (0.65) | ARNR3C1 | |
| SCHEMBL30184879 | 0.85 | AR (0.75) | ARNR3C1 | |
| SCHEMBL547406 | 0.85 | AR (0.65) | ARNR3C1 | |
| SCHEMBL547047 | 0.85 | AR (0.75) | ARNR3C1 | |
| SCHEMBL29508773 | 0.84 | AR (0.64) | ARNR3C1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9126941-B2 | Treatment of hyperproliferative disorders with diarylhydantoin compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-09-08 | — | — | US | disclosed |
| US-8658681-B2 | — | — | 2014-02-25 | — | — | US | disclosed |
| US-8648105-B2 | Diarylthiohydantoin compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-11 | — | — | US | disclosed |