Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877634 | 1.00 | PDE4D (0.43) | PDE4DSYKMKNK1MKNK2EIF4E | |
| SCHEMBL15696504 | 1.00 | PDE4D (0.43) | PDE4DSYKMKNK1MKNK2EIF4E | |
| SCHEMBL24780615 | 0.91 | SYK (0.51) | PDE4DSYKMKNK1MKNK2GRM5 | |
| SCHEMBL24498739 | 0.88 | SYK (0.46) | PDE4DSYKGRM5PDE4APDE4B | |
| SCHEMBL15696516 | 0.84 | SLC6A2 (0.40) | SLC6A2SLC6A4 | |
| SCHEMBL24925309 | 0.82 | SCD (0.44) | SYKMKNK1MKNK2EIF4ESLC6A2 | |
| SCHEMBL17353216 | 0.82 | SCD (0.44) | PDE4DMKNK1MKNK2EIF4EPDE4A | |
| SCHEMBL2409363 | 0.82 | NTRK1 (0.42) | PDE4DSYKMKNK1MKNK2EIF4E | |
| SCHEMBL2406266 | 0.82 | NTRK1 (0.42) | PDE4DSYKMKNK1MKNK2EIF4E | |
| SCHEMBL17353214 | 0.82 | SCD (0.44) | PDE4DMKNK1MKNK2EIF4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648068-B2 | Heterocycloalkyl-containing thienopyrimidines for pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-11 | — | — | US | disclosed |