Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14549255 | 0.92 | MAP2K1 (0.65) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL391319 | 0.90 | MAP2K1 (0.79) | MAP2K1MAP2K2 | |
| SCHEMBL14549242 | 0.82 | MAP2K1 (0.81) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL387602 | 0.81 | MAP2K1 (0.80) | MAP2K1MAP2K2 | |
| SCHEMBL14549223 | 0.80 | MAP2K1 (0.61) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL393715 | 0.80 | MAP2K1 (0.81) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL392922 | 0.79 | MAP2K1 (0.83) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL392824 | 0.79 | MAP2K1 (0.72) | MAP2K1MEN1KMT2ATDP1 | |
| SCHEMBL14549235 | 0.78 | MAP2K1 (0.50) | MAP2K1MAP2K2 | |
| SCHEMBL391364 | 0.78 | MAP2K1 (0.72) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | disclosed |