Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | BCL3 | P20749 | 4/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391994 | 0.89 | MAP2K1 (0.64) | MAP2K1MAP2K2CNR2CNR1SMN1; SMN2 | |
| SCHEMBL14549260 | 0.81 | MAP2K1 (0.49) | MAP2K1MAP2K2 | |
| SCHEMBL14549249 | 0.78 | MAP2K1 (0.47) | MAP2K1MAP2K2CNR2CNR1 | |
| SCHEMBL14549236 | 0.78 | MAP2K1 (0.49) | MAP2K1MAP2K2 | |
| SCHEMBL13070203 | 0.75 | MAP2K1 (0.52) | MAP2K1MAP2K2GSK3BTOP2A | |
| SCHEMBL392824 | 0.74 | MAP2K1 (0.72) | MAP2K1 | |
| SCHEMBL14549235 | 0.74 | MAP2K1 (0.50) | MAP2K1MAP2K2 | |
| SCHEMBL14549075 | 0.73 | MAP2K1 (0.47) | MAP2K1MAP2K2 | |
| SCHEMBL27659392 | 0.73 | MAP2K1 (0.72) | MAP2K1MAP2K2 | |
| SCHEMBL392317 | 0.71 | MAP2K1 (0.66) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | disclosed |