Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 1.00 |
| ▸ | PLK4 | O00444 | 3/20 | 1.00 |
| ▸ | DYRK3 | O43781 | 3/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 3/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 3/20 | 1.00 |
| ▸ | AKT1 | P31749 | 3/20 | 1.00 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 1.00 |
| ▸ | CLK2 | P49760 | 3/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 1.00 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 1.00 |
| ▸ | CAMK2D | Q13557 | 3/20 | 1.00 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 1.00 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 1.00 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 3/20 | 1.00 |
| ▸ | PBK | Q96KB5 | 3/20 | 1.00 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 1.00 |
| ▸ | SLK | Q9H2G2 | 3/20 | 1.00 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501644 | 0.84 | CDC7 (1.00) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613359 | 0.83 | PTPN7 (0.77) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613324 | 0.81 | PTPN7 (0.82) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL6238251 | 0.81 | PTPN7 (1.00) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613329 | 0.79 | PTPN7 (0.79) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613375 | 0.79 | PTPN7 (1.00) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613383 | 0.79 | PTPN7 (0.82) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613384 | 0.79 | IKBKB (1.00) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613328 | 0.78 | PTPN7 (1.00) | CDC7PLK4DYRK3PRKD3MAP4K4 | |
| SCHEMBL9613362 | 0.78 | PTPN7 (0.88) | CDC7PLK4DYRK3PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2014-02-20 | — | — | US | claimed |
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | PPIG, FKBP1B, PPIH | CDC7 3217/4885PLK4 3667/4885DYRK3 4340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.