Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 18/20 | 0.82 |
| ▸ | HDAC4 | P56524 | 18/20 | 0.82 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.82 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.82 |
| ▸ | HDAC2 | Q92769 | 18/20 | 0.82 |
| ▸ | HDAC10 | Q969S8 | 18/20 | 0.82 |
| ▸ | HDAC11 | Q96DB2 | 18/20 | 0.82 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.82 |
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.82 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.82 |
| ▸ | HDAC5 | Q9UQL6 | 18/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1547210 | 1.00 | HDAC3 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1547333 | 0.94 | HDAC3 (0.83) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1547331 | 0.94 | HDAC3 (0.83) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1547187 | 0.91 | HDAC3 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1546910 | 0.91 | HDAC3 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1547158 | 0.90 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1547252 | 0.89 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1176250 | 0.89 | HDAC3 (0.81) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1176246 | 0.89 | HDAC3 (0.81) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1547249 | 0.89 | HDAC3 (0.66) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311840-A1 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC S.r.l. (IT) | 2011-04-20 | — | — | EP | disclosed |