Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | PPARA | Q07869 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12831290 | 0.93 | ANO1 (0.58) | PPARGPPARARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12756883 | 0.87 | MAPT (0.48) | PPARGPPARARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12756890 | 0.87 | PPARG (0.56) | PPARGPPARARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1490743 | 0.84 | KCNK3 (0.50) | PPARGPPARANPC1TP53MAPT | |
| SCHEMBL1490227 | 0.82 | MEN1 (0.49) | RAB9ASMN1; SMN2NPC1ANO1MAPT | |
| SCHEMBL12756881 | 0.82 | PPARG (0.49) | PPARGPPARARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL13819654 | 0.82 | ANO1 (0.71) | PPARGPPARARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12756888 | 0.81 | NPC1 (0.45) | RAB9ASMN1; SMN2NPC1ANO1TP53 | |
| SCHEMBL12831284 | 0.81 | ANO1 (0.56) | PPARGPPARARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12831286 | 0.81 | MAPT (0.45) | RAB9ANPC1ANO1MAPTGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | PPARG 1551/4885PPARA 2210/4885RAB9A 1174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.