Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.70 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.64 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.64 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23054850 | 0.94 | EPHX2 (0.61) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL8286919 | 0.87 | HDAC1 (0.56) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL31635263 | 0.87 | HDAC1 (0.83) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL8132303 | 0.86 | HDAC1 (0.55) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL15480429 | 0.86 | HDAC1 (0.68) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL7365312 | 0.86 | HDAC1 (0.73) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL4096977 | 0.86 | HDAC1 (0.55) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL5547454 | 0.86 | HDAC1 (0.53) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL8180029 | 0.86 | HDAC1 (0.55) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL8180976 | 0.84 | EPHX2 (0.54) | HDAC1HDAC6HDAC2HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210060014-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB (SE) | 2021-03-04 | — | — | US | disclosed |
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENT AB (SE) | 2017-01-26 | — | — | US | disclosed |
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC1 2/4885HDAC6 10/4885HDAC2 3/4885 |
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC1 2/4885HDAC6 10/4885HDAC2 3/4885 |
| US-20210060014-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC1 2/4885HDAC6 10/4885HDAC2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.