Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.84 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.84 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.84 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.84 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.84 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.84 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.84 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.84 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.84 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.84 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.84 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.84 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Givinostat SCHEMBL1555814 | 0.91 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| Givinostat SCHEMBL29361624 | 0.91 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| Givinostat SCHEMBL30527230 | 0.90 | HDAC6 (0.98) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| Givinostat SCHEMBL1554636 | 0.90 | HDAC6 (0.98) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| Givinostat SCHEMBL2468061 | 0.89 | HDAC6 (0.96) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL25726578 | 0.89 | HDAC6 (0.80) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL2336213 | 0.89 | HDAC6 (0.80) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL23563425 | 0.88 | HDAC6 (0.78) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL23563367 | 0.88 | HDAC6 (0.78) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL22071363 | 0.86 | HDAC6 (0.75) | HDAC6HDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENT AB (SE) | 2017-01-26 | — | — | US | disclosed |
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC6 10/4885HDAC1 2/4885HDAC8 4/4885 |
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC6 10/4885HDAC1 2/4885HDAC8 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.