Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3760531 | 0.88 | PIK3CA (0.39) | PIK3CAMAP4K1 | |
| SCHEMBL3759676 | 0.88 | PIK3CA (0.34) | PIK3CA | |
| SCHEMBL857247 | 0.88 | PIK3CA (0.39) | PIK3CA | |
| SCHEMBL861757 | 0.86 | PIK3CA (0.35) | PIK3CARET | |
| SCHEMBL859032 | 0.85 | PIK3CA (0.39) | PIK3CAMAP4K1 | |
| SCHEMBL856926 | 0.84 | PIK3CA (0.40) | PIK3CARETMAP4K1 | |
| SCHEMBL15605838 | 0.83 | PIK3CA (0.32) | PIK3CA | |
| SCHEMBL856497 | 0.82 | AURKA (0.36) | PIK3CARET | |
| SCHEMBL856970 | 0.82 | PIK3CA (0.34) | PIK3CARET | |
| SCHEMBL8880661 | 0.82 | PIK3CA (0.45) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066431-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066431-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | PIK3CA 3/4885RET 2276/4885MAP4K1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.