Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 14/20 | 0.48 |
| ▸ | PPARG | P37231 | 11/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 11/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1549631 | 0.92 | PPARA (0.49) | PPARAPPARGRIPK1PPARD | |
| SCHEMBL1548373 | 0.91 | PPARA (0.56) | PPARAPPARGRIPK1PPARD | |
| SCHEMBL6106937 | 0.90 | PPARA (0.57) | PPARAPPARGPPARDTP53MAPT | |
| SCHEMBL1549979 | 0.90 | PPARA (0.47) | PPARAPPARGPPARDTP53MAPT | |
| SCHEMBL1549853 | 0.87 | PPARA (0.47) | PPARAPPARGPPARDTP53MAPT | |
| SCHEMBL1549943 | 0.83 | PPARA (0.56) | PPARAPPARGPPARD | |
| SCHEMBL1548887 | 0.83 | PPARA (0.46) | PPARAPPARGRIPK1PPARD | |
| SCHEMBL1549118 | 0.82 | PPARA (0.59) | PPARAPPARGPPARD | |
| SCHEMBL5669949 | 0.81 | PPARA (0.44) | PPARAPPARGPPARD | |
| SCHEMBL5667232 | 0.81 | PPARA (0.42) | PPARAPPARGPPARDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2314576-A1 | Phenyl derivatives as PPAR agonists | F.HOFFMANN-LA ROCHE AG (CH) | 2011-04-27 | — | — | EP | disclosed |
| US-7115611-B2 | Phenyl derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1682508-A1 | PHENYL DERIVATIVES AS PPAR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049573-A1 | PHENYL DERIVATIVES AS PPAR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |
| US-20050096337-A1 | Phenyl derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096337-A1 | Phenyl derivatives, their manufacture and use as pharmaceutical agents | PPARD, PPARA, PPARG | PPARA 2/4885PPARG 3/4885RIPK1 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.