Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.55 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1549722 | 0.99 | PARP1 (0.69) | PARP1TNKS2PARP15PARP10PARP2 | |
| SCHEMBL16472187 | 0.83 | PARP1 (0.71) | PARP1TNKS2PARP15PARP10PARP2 | |
| SCHEMBL1549708 | 0.82 | PARP1 (0.70) | PARP1TNKS2PARP15PARP10TNKS | |
| SCHEMBL424273 | 0.81 | PARP1 (0.97) | PARP1TNKS2PARP15PARP10PARP2 | |
| Hydrochloric Acid SCHEMBL1549716 | 0.81 | PARP1 (0.72) | PARP1TNKS2PARP15PARP10TNKS | |
| Hydrochloric Acid SCHEMBL4326979 | 0.80 | PARP1 (1.00) | PARP1TNKS2PARP15PARP10PARP2 | |
| SCHEMBL1549402 | 0.77 | PARP1 (0.70) | PARP1LMNATNKSALDH1A1 | |
| Hydrochloric Acid SCHEMBL1549814 | 0.76 | PARP1 (0.72) | PARP1LMNATNKSALDH1A1 | |
| SCHEMBL1549386 | 0.76 | PARP1 (0.69) | PARP1TNKS2PARP2KDM4ETNKS | |
| Hydrochloric Acid SCHEMBL4326864 | 0.75 | PARP1 (0.68) | PARP1TNKS2PARP2KDM4ETNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313418-B1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | PELLICCIARI ROBERTO (IT) | 2016-03-30 | — | — | EP | claimed |
| JP-2011525186-A | — | — | 2011-09-15 | — | — | JP | claimed |
| EP-2313418-A1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | Wyeth LLC (US) | 2011-04-27 | — | — | EP | claimed |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-31 | — | — | US | claimed |
| WO-2009155413-A1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-23 | — | — | WO | claimed |
| EP-2313418-B1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | PELLICCIARI ROBERTO (IT) | 2016-03-30 | — | — | EP | disclosed |
| US-9079915-B2 | Thienyl- and furanyl-isoquinolinones and methods for using them | Pellicciari, Robert (IT) | 2015-07-14 | — | — | US | disclosed |
| US-20140107117-A1 | Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them | Moroni, Flavio (IT) | 2014-04-17 | — | — | US | disclosed |
| US-8633215-B2 | Thienyl-and furanyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2014-01-21 | — | — | US | disclosed |
| US-8633215-B2 | Thienyl-and furanyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2014-01-21 | — | — | US | disclosed |
| EP-2313418-A1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | Wyeth LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
| WO-2009155413-A1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009155413-A1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107117-A1 | Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them | PARP1, PARP2, PARP15 | PARP1 1/4885TNKS2 20/4885PARP15 3/4885 |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | PARP1, PARP2, PARP15 | PARP1 1/4885TNKS2 20/4885PARP15 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.