Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18811612 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2RORCTMIGD3ADORA1ALDH1A1 | |
| SCHEMBL9261452 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2RORCTMIGD3ADORA1ALDH1A1 | |
| SCHEMBL21510767 | 0.99 | SMN1; SMN2 (0.47) | SMN1; SMN2RORCTMIGD3ADORA1ALDH1A1 | |
| SCHEMBL9094106 | 0.96 | SMN1; SMN2 (0.44) | SMN1; SMN2RORCTMIGD3ADORA1ALDH1A1 | |
| SCHEMBL577947 | 0.93 | TMIGD3 (0.47) | SMN1; SMN2TMIGD3ADORA1ALDH1A1HPGD | |
| SCHEMBL21063663 | 0.83 | MAPT (0.40) | SMN1; SMN2ALDH1A1MAPTMEN1NPC1 | |
| SCHEMBL16445934 | 0.80 | CDK5 (0.39) | SMN1; SMN2TMIGD3ADORA1ALDH1A1MAPT | |
| SCHEMBL15537682 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL15551276 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL17709829 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018380-B2 | Heterocyclic modulators of HIF activity for treatment of disease | Boar of Regents, The University of Texas System (US) | 2015-04-28 | — | — | US | disclosed |
| US-20140066424-A1 | HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE | Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066424-A1 | HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE | HIF1AN, HIF1A, EGLN3 | SMN1; SMN2 4052/4885RORC 1343/4885TMIGD3 3847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.