Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 3/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 8/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326481 | 0.94 | KDR (0.47) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4324526 | 0.91 | KDR (0.48) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4332993 | 0.90 | KDR (0.48) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4318354 | 0.89 | RAF1 (0.55) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4336983 | 0.87 | KDR (0.46) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4321789 | 0.86 | CYP1A2 (0.49) | KDRTEKEPHB4RAF1MLYCD | |
| SCHEMBL4325571 | 0.81 | RAF1 (0.47) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4321699 | 0.81 | KDR (0.51) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4323326 | 0.80 | RAF1 (0.57) | KDRTEKEPHB4RAF1BRAF | |
| SCHEMBL4325587 | 0.80 | KDR (0.44) | KDRTEKEPHB4RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858877-B1 | 1,3 SUBSTITUTED DIARYL UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2014-03-12 | — | — | EP | disclosed |