SCHEMBL15501147

CO[C@H](C)C(NC(=O)OC(C)(C)C)C(=O)N1CC[C@H](OC(C)=O)[C@H]1Cc1c(-c2[nH]c3cc(F)ccc3c2C[C@@H]2[C@@H](OC(C)=O)CCN2C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC)[nH]c2cc(F)ccc12

nearest known ligand 0.39

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	BIRC3	Q13489	13/20	0.39

▸	XIAP	P98170	9/20	0.39

▸	BIRC2	Q13490	1/20	0.39

▸	BIRC7	Q96CA5	1/20	0.39

▸	TNF	P01375	12/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12405720	1.00	BIRC3 (0.39)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL12474013	0.97	BIRC3 (0.38)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL10109908	0.95	BIRC3 (0.47)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL820543	0.93	BIRC3 (0.34)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL819050	0.93	BIRC3 (0.34)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL12405729	0.89	BIRC3 (0.39)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL10109956	0.88	BIRC3 (0.51)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL12405733	0.88	BIRC3 (0.51)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL15501163	0.88	BIRC3 (0.51)	BIRC3XIAPBIRC2BIRC7TNF
SCHEMBL14304341	0.88	BIRC3 (0.51)	BIRC3XIAPBIRC2BIRC7TNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2049563-B1	DIMERIC IAP ANTAGONISTS	TETRALOGIC PHARM CORP (US)	2014-03-12	—	—	EP	disclosed