Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 1.00 |
| ▸ | CTSD | P07339 | 16/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996360 | 0.90 | BACE1 (0.82) | BACE1CTSDKCNH2 | |
| SCHEMBL1996362 | 0.90 | BACE1 (0.82) | BACE1CTSDKCNH2 | |
| SCHEMBL2371563 | 0.87 | BACE1 (1.00) | BACE1CTSDKCNH2 | |
| SCHEMBL2382423 | 0.87 | BACE1 (1.00) | BACE1CTSDKCNH2 | |
| SCHEMBL2009097 | 0.87 | BACE1 (0.77) | BACE1CTSDKCNH2 | |
| SCHEMBL2000332 | 0.87 | BACE1 (0.81) | BACE1CTSDKCNH2 | |
| SCHEMBL2000335 | 0.87 | BACE1 (0.81) | BACE1CTSDKCNH2 | |
| SCHEMBL2382289 | 0.85 | BACE1 (1.00) | BACE1CTSDKCNH2 | |
| SCHEMBL2371883 | 0.85 | BACE1 (1.00) | BACE1CTSDKCNH2 | |
| SCHEMBL2524170 | 0.84 | BACE1 (1.00) | BACE1CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |