Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15509542 | 0.86 | CNR2 (0.51) | BACE1KCNH2KMT2ACTSDCNR2 | |
| SCHEMBL3272891 | 0.83 | MEN1 (0.44) | ROCK2MEN1KMT2AHDAC6CA2 | |
| SCHEMBL3272894 | 0.77 | BACE1 (0.41) | BACE1KCNH2NAMPTCNR2 | |
| SCHEMBL15509908 | 0.77 | HPGD (0.46) | BACE1CTSDCNR2 | |
| SCHEMBL6845308 | 0.74 | BACE1 (0.58) | BACE1KCNH2MEN1KMT2ACTSD | |
| SCHEMBL2371257 | 0.73 | BACE1 (0.54) | BACE1KCNH2CTSD | |
| SCHEMBL15518146 | 0.73 | BACE1 (0.68) | BACE1KCNH2CTSD | |
| SCHEMBL15510201 | 0.71 | BACE1 (0.59) | BACE1KCNH2CTSD | |
| SCHEMBL13383464 | 0.70 | BACE1 (0.54) | BACE1CTSD | |
| SCHEMBL15510232 | 0.69 | BACE1 (0.59) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |