Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371914 | 1.00 | BACE1 (0.64) | BACE1CTSD | |
| SCHEMBL2371917 | 1.00 | BACE1 (0.64) | BACE1CTSD | |
| SCHEMBL2370457 | 0.92 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL2370464 | 0.92 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL2370905 | 0.92 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL12212379 | 0.88 | BACE1 (0.53) | BACE1CTSD | |
| SCHEMBL12213323 | 0.86 | BACE1 (0.50) | BACE1CTSD | |
| SCHEMBL7916535 | 0.86 | BACE1 (0.50) | BACE1CTSD | |
| SCHEMBL2525931 | 0.86 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2525930 | 0.86 | BACE1 (0.48) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |