Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.62 |
| ▸ | CTSD | P07339 | 7/20 | 0.57 |
| ▸ | CTSE | P14091 | 1/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371170 | 0.92 | BACE1 (0.63) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2371178 | 0.92 | BACE1 (0.63) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL6845317 | 0.90 | BACE1 (0.69) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1998208 | 0.87 | BACE1 (0.73) | BACE1KCNH2CTSD | |
| SCHEMBL1995219 | 0.87 | BACE1 (0.65) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1995217 | 0.87 | BACE1 (0.65) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15510129 | 0.84 | BACE1 (0.62) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL12212454 | 0.84 | BACE1 (0.68) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2000622 | 0.83 | BACE1 (0.66) | BACE1KCNH2CTSD | |
| SCHEMBL2000626 | 0.83 | BACE1 (0.66) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |