Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.43 |
| ▸ | CTSD | P07339 | 14/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15510372 | 1.00 | BACE1 (0.43) | BACE1CTSDKCNH2 | |
| SCHEMBL2371257 | 0.81 | BACE1 (0.54) | BACE1CTSDKCNH2 | |
| SCHEMBL13383464 | 0.79 | BACE1 (0.54) | BACE1CTSD | |
| SCHEMBL3278041 | 0.78 | BACE1 (0.52) | BACE1CTSDKCNH2 | |
| SCHEMBL15510205 | 0.77 | BACE1 (0.53) | BACE1CTSDKCNH2 | |
| SCHEMBL2371022 | 0.76 | BACE1 (0.54) | BACE1CTSD | |
| SCHEMBL3273790 | 0.75 | BACE1 (0.44) | BACE1CTSDKCNH2 | |
| SCHEMBL2522795 | 0.75 | BACE1 (0.39) | BACE1CTSDKCNH2 | |
| SCHEMBL2522306 | 0.73 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL3273268 | 0.72 | BACE1 (0.51) | BACE1CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |