Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.63 |
| ▸ | FLT3 | P36888 | 12/20 | 0.63 |
| ▸ | KIT | P10721 | 12/20 | 0.63 |
| ▸ | CSF1R | P07333 | 7/20 | 0.63 |
| ▸ | FLT1 | P17948 | 6/20 | 0.63 |
| ▸ | FLT4 | P35916 | 5/20 | 0.63 |
| ▸ | LCK | P06239 | 4/20 | 0.63 |
| ▸ | BLK | P51451 | 5/20 | 0.61 |
| ▸ | LYN | P07948 | 4/20 | 0.61 |
| ▸ | AURKA | O14965 | 3/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041792 | 0.98 | KDR (0.65) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL15512939 | 0.97 | KDR (0.61) | KDRFLT3KITCSF1RFLT1 | |
| Dimethylcarbate SCHEMBL15512513 | 0.95 | KDR (0.59) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL15513151 | 0.95 | KDR (0.59) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13041761 | 0.91 | KDR (0.54) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13041752 | 0.89 | KDR (0.54) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13041781 | 0.89 | KIT (0.58) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13041808 | 0.89 | KDR (0.52) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13041795 | 0.88 | KDR (0.54) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13041804 | 0.88 | FLT1 (0.53) | KDRFLT3KITCSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032572-B1 | Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them | BAYER IP GMBH (DE) | 2014-03-12 | — | — | EP | claimed |