Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.68 |
| ▸ | FLT3 | P36888 | 11/20 | 0.68 |
| ▸ | KIT | P10721 | 10/20 | 0.68 |
| ▸ | FLT1 | P17948 | 8/20 | 0.68 |
| ▸ | CSF1R | P07333 | 7/20 | 0.68 |
| ▸ | FLT4 | P35916 | 5/20 | 0.68 |
| ▸ | LCK | P06239 | 4/20 | 0.68 |
| ▸ | LYN | P07948 | 4/20 | 0.68 |
| ▸ | SRC | P12931 | 4/20 | 0.68 |
| ▸ | BLK | P51451 | 4/20 | 0.68 |
| ▸ | FYN | P06241 | 4/20 | 0.68 |
| ▸ | ABL1 | P00519 | 3/20 | 0.68 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.61 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.61 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.61 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL15513275 | 0.98 | KDR (0.68) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2821104 | 0.98 | KDR (0.70) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL15512726 | 0.96 | KDR (0.65) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL15512422 | 0.96 | KDR (0.65) | KDRFLT3KITFLT1CSF1R | |
| Dimethylcarbate SCHEMBL15512477 | 0.95 | KDR (0.64) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2816848 | 0.95 | KDR (0.68) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2817427 | 0.94 | KDR (0.67) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL15512783 | 0.94 | KIT (0.63) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL15512555 | 0.94 | KDR (0.63) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL15512441 | 0.93 | KIT (0.62) | KDRFLT3KITFLT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032572-B1 | Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them | BAYER IP GMBH (DE) | 2014-03-12 | — | — | EP | claimed |