Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 10/20 | 0.52 |
| ▸ | CSNK1E | P49674 | 10/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247635 | 0.86 | KDR (0.43) | CSNK1DCSNK1EKDRAURKAPDGFRB | |
| SCHEMBL251711 | 0.78 | CSNK1D (0.53) | CSNK1DCSNK1EKDRKDM4EALDH1A1 | |
| SCHEMBL5954875 | 0.77 | CSNK1D (0.52) | CSNK1DCSNK1EKDRAURKAPDGFRB | |
| SCHEMBL5954787 | 0.76 | CSNK1D (0.51) | CSNK1DCSNK1EKDRAURKAPDGFRB | |
| SCHEMBL253801 | 0.76 | CSNK1D (0.51) | CSNK1DCSNK1EKDRAURKAPDGFRB | |
| SCHEMBL5955070 | 0.76 | KDR (0.42) | CSNK1DCSNK1EKDRAURKAPDGFRB | |
| SCHEMBL5955078 | 0.76 | KDR (0.42) | CSNK1DCSNK1EKDRMET | |
| SCHEMBL5955206 | 0.76 | KDR (0.43) | CSNK1DCSNK1EKDRAURKAPDGFRB | |
| SCHEMBL5955401 | 0.75 | KDR (0.43) | CSNK1DCSNK1EKDRMET | |
| SCHEMBL5954582 | 0.73 | GSK3B (0.48) | CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313407-A1 | cMET INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |