Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2073828 | 0.96 | HDAC1 (0.55) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15513596 | 0.86 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL5278889 | 0.85 | HDAC1 (0.72) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15512681 | 0.85 | HDAC1 (0.62) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15512662 | 0.84 | HDAC1 (0.61) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15513307 | 0.82 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| Trifluoroacetic Acid SCHEMBL2073863 | 0.82 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15512687 | 0.82 | HDAC1 (0.71) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL15513570 | 0.82 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| Trifluoroacetic Acid SCHEMBL2070700 | 0.81 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828171-B1 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2014-03-12 | — | — | EP | claimed |