Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331398 | 0.87 | MAPT (0.56) | GAAKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL4323882 | 0.79 | EPHB4 (0.56) | GAAKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL4326485 | 0.77 | EPHB4 (0.56) | GAAKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL4325575 | 0.77 | EPHB4 (0.56) | GAAKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL4332950 | 0.76 | EPHB4 (0.56) | GAAKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL15512978 | 0.75 | LIMK2 (0.34) | GAAKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL4329653 | 0.74 | EPHB4 (0.56) | GAAKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL4330165 | 0.74 | MAPK14 (0.49) | GAAKMT2AMAPTMEN1USP2 | |
| SCHEMBL4321685 | 0.74 | EPHB4 (0.58) | GAAKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL4331400 | 0.73 | EPHB4 (0.40) | GAALMNAMAPTUSP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858877-B1 | 1,3 SUBSTITUTED DIARYL UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2014-03-12 | — | — | EP | disclosed |