Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 8/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 5/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 2/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15513671 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL27832013 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL2073565 | 0.99 | HDAC1 (0.98) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| Trifluoroacetic Acid SCHEMBL2074447 | 0.95 | HDAC1 (0.90) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| Trifluoroacetic Acid SCHEMBL2073355 | 0.95 | HDAC1 (0.90) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL27701517 | 0.93 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL15513542 | 0.93 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL2072886 | 0.92 | HDAC1 (0.85) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL15707232 | 0.92 | HDAC1 (0.85) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL2071796 | 0.91 | HDAC1 (0.84) | HDAC1HDAC3HDAC6HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828171-B1 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2014-03-12 | — | — | EP | claimed |
| CN-101115742-A | Heterocycle derivatives as histone deacetylase (hdac) inhibitors | ANGELETTI P IST RICHERCHE BIO (IT) | 2008-01-30 | — | — | CN | disclosed |