Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.74 |
| ▸ | CTSD | P07339 | 5/20 | 0.66 |
| ▸ | CTSE | P14091 | 1/20 | 0.60 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15509945 | 0.91 | BACE1 (0.80) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15510037 | 0.88 | BACE1 (0.80) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15509808 | 0.87 | BACE1 (0.75) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1998711 | 0.86 | BACE1 (0.79) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15509902 | 0.86 | BACE1 (0.73) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15510209 | 0.85 | BACE1 (1.00) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15509774 | 0.84 | BACE1 (0.81) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2000400 | 0.84 | BACE1 (0.75) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2001459 | 0.84 | BACE1 (0.75) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2019058 | 0.84 | BACE1 (1.00) | BACE1KCNH2CTSDCTSEBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |