Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.81 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27863820 | 0.92 | AKT1 (0.80) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1028435 | 0.90 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL931988 | 0.89 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1029803 | 0.88 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1031125 | 0.88 | AKT1 (0.83) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1031851 | 0.88 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1030935 | 0.87 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL12956340 | 0.87 | AKT1 (0.81) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1030422 | 0.87 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1029891 | 0.85 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448927-B1 | NOVEL (6-OXO-1, 6-DIHYDRO-PYRIMIDIN-2-YL)-AMIDE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT PHOSPHORYLATION INHIBITORS | SANOFI SA (FR) | 2014-03-12 | — | — | EP | claimed |