Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15519153 | 0.90 | MAPT (0.46) | MAPTLPAR1CSNK2A1PLATNSD2 | |
| SCHEMBL15518353 | 0.86 | MAPT (0.49) | MAPTLPAR1CSNK2A1NSD2MEN1 | |
| SCHEMBL15518354 | 0.85 | MAPT (0.58) | MAPTLPAR1CSNK2A1KDM4EALDH1A1 | |
| SCHEMBL15518351 | 0.84 | MAPT (0.57) | MAPTLPAR1CSNK2A1KDM4EALDH1A1 | |
| SCHEMBL15518388 | 0.84 | MAPT (0.47) | MAPTCSNK2A1MEN1NPC1RAB9A | |
| SCHEMBL15518062 | 0.82 | MAPT (0.44) | MAPTCSNK2A1PLATNSD2KDM4E | |
| SCHEMBL15518108 | 0.79 | MAPT (0.49) | MAPTLPAR1CSNK2A1KDM4EALDH1A1 | |
| SCHEMBL15518754 | 0.72 | MAPT (0.52) | MAPTLPAR1CSNK2A1PLATALDH1A1 | |
| SCHEMBL15518216 | 0.71 | MAPT (0.38) | MAPTLPAR1CSNK2A1PLATKDM4E | |
| SCHEMBL15517867 | 0.70 | MAPT (0.43) | MAPTLPAR1CSNK2A1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169215-B2 | LPAR—substituted cyanopyrazole compounds | HOFFMANN-LA ROCHE INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20150218106-A1 | LPAR - SUBSTITUTED CYANOPYRAZOLE COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2015-08-06 | — | — | US | disclosed |
| EP-2892882-A1 | LPAR - SUBSTITUTED CYANOPYRAZOLE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014037303-A1 | LPAR - SUBSTITUTED CYANOPYRAZOLE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218106-A1 | LPAR - SUBSTITUTED CYANOPYRAZOLE COMPOUNDS | LPAR3, LPAR1, LPAR2 | MAPT 4773/4885LPAR1 2/4885CSNK2A1 884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.