Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.52 |
| ▸ | GALR3 | O60755 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 7/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.48 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15519686 | 0.87 | AURKA (0.53) | HDAC1EGFRLMNAMAPK1AURKA | |
| SCHEMBL15520428 | 0.85 | DNMT1 (0.58) | HDAC1EGFRRAB9AAURKAAURKB | |
| SCHEMBL15519619 | 0.85 | AURKA (0.61) | HDAC1AURKAAURKBRPS6KB1PDPK1 | |
| SCHEMBL15519797 | 0.84 | KDR (0.60) | EGFRLMNAMAPK1HTTAURKA | |
| SCHEMBL15519021 | 0.82 | KDR (0.51) | HDAC1EGFRLMNAMAPK1HTT | |
| SCHEMBL15518884 | 0.81 | HDAC1 (1.00) | HDAC1EGFRNR2F2GALR3RAB9A | |
| SCHEMBL15579859 | 0.79 | HDAC1 (0.80) | HDAC1EGFRNR2F2GALR3RAB9A | |
| SCHEMBL1565884 | 0.79 | NAMPT (0.55) | HDAC1MAPK1HDAC6 | |
| SCHEMBL15519022 | 0.78 | HDAC1 (1.00) | HDAC1EGFRNR2F2GALR3RAB9A | |
| SCHEMBL15519871 | 0.76 | HDAC1 (0.71) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9034886-B2 | 4-aminoquinazoline derivatives and uses thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2015-05-19 | — | — | US | claimed |
| US-20140235633-A1 | 4-Aminoquinazoline Derivatives and Uses Thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2014-08-21 | — | — | US | claimed |
| EP-2708532-A1 | 4-AMINOQUINAZOLINE DERIVATIVES AND USES THEREOF | Jiangsu Hengyi Pharmaceutical Co.,Ltd (CN) | 2014-03-19 | — | — | EP | claimed |
| US-9034886-B2 | 4-aminoquinazoline derivatives and uses thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2015-05-19 | — | — | US | disclosed |
| US-20140235633-A1 | 4-Aminoquinazoline Derivatives and Uses Thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2014-08-21 | — | — | US | disclosed |
| EP-2708532-A1 | 4-AMINOQUINAZOLINE DERIVATIVES AND USES THEREOF | Jiangsu Hengyi Pharmaceutical Co.,Ltd (CN) | 2014-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235633-A1 | 4-Aminoquinazoline Derivatives and Uses Thereof | HDAC5, HDAC4, HDAC1 | HDAC1 3/4885EGFR 3198/4885NR2F2 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.