Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520713 | 0.99 | KDR (0.47) | KDRAURKACHEK1 | |
| SCHEMBL15520144 | 0.85 | KDR (0.49) | KDRAURKACHEK1PDGFRBPDGFRA | |
| SCHEMBL15520214 | 0.84 | KDR (0.48) | KDRAURKACHEK1 | |
| SCHEMBL15520809 | 0.82 | KDR (0.41) | KDRAURKAPDGFRBPDGFRAFLT3 | |
| SCHEMBL15520142 | 0.82 | KDR (0.49) | KDRAURKACHEK1PDGFRBPDGFRA | |
| SCHEMBL15520143 | 0.81 | KDR (0.45) | KDRAURKACHEK1PDGFRBPDGFRA | |
| SCHEMBL15520211 | 0.81 | KDR (0.48) | KDRAURKACHEK1PDGFRBPDGFRA | |
| SCHEMBL15520726 | 0.81 | KDR (0.38) | KDRAURKAPDGFRBPDGFRA | |
| SCHEMBL15520212 | 0.80 | KDR (0.43) | KDRAURKACHEK1PDGFRBPDGFRA | |
| SCHEMBL15520113 | 0.77 | CHEK1 (0.62) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294065-B1 | INDOLYL-PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS R&D LTD (GB) | 2014-03-19 | — | — | EP | claimed |