Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 16/20 | 0.73 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552635 | 0.95 | CHEK2 (0.74) | CHEK2ROCK2CCR2ROCK1 | |
| SCHEMBL1553018 | 0.95 | CHEK2 (0.72) | CHEK2BCHEACHEROCK2CCR2 | |
| SCHEMBL1553011 | 0.90 | CHEK2 (0.87) | CHEK2OPRK1 | |
| SCHEMBL1552720 | 0.87 | CHEK2 (0.74) | CHEK2ROCK2CCR2ROCK1 | |
| SCHEMBL1552268 | 0.85 | CHEK2 (0.88) | CHEK2ROCK2CCR2ROCK1 | |
| SCHEMBL1552711 | 0.84 | CHEK2 (0.75) | CHEK2 | |
| SCHEMBL5638333 | 0.84 | CHEK2 (0.72) | CHEK2ACHEROCK2CCR2ROCK1 | |
| SCHEMBL1552266 | 0.84 | CHEK2 (0.87) | CHEK2OPRK1 | |
| SCHEMBL1552763 | 0.84 | CHEK2 (0.74) | CHEK2BCHEACHE | |
| SCHEMBL1552337 | 0.84 | CHEK2 (0.69) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824832-B1 | ARYL-SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE ETHERS AS ANTI-CANCER AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-27 | — | — | EP | claimed |