Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.62 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.62 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.62 |
| ▸ | NT5E | P21589 | 2/20 | 0.54 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.48 |
| ▸ | KRAS | P01116 | 2/20 | 0.48 |
| ▸ | TYMP | P19971 | 1/20 | 0.48 |
| ▸ | HINT1 | P49773 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.47 |
| ▸ | DTYMK | P23919 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24059956 | 0.93 | POLB (0.77) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL20276932 | 0.93 | POLB (0.77) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL6917413 | 0.93 | POLB (0.77) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL20282863 | 0.93 | POLB (0.77) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL20277563 | 0.93 | POLB (0.77) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL503124 | 0.92 | POLB (0.78) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL48232 | 0.91 | POLB (0.82) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL25171429 | 0.91 | POLB (0.82) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL1971161 | 0.91 | POLB (0.82) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL16678590 | 0.91 | POLB (0.82) | POLBP2RY2P2RY4P2RY6NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200239884-A1 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION | UNIV MIAMI (US) | 2020-07-30 | — | — | US | disclosed |
| US-10443056-B2 | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation | NOGRA PHARMA LIMITED (IE) | 2019-10-15 | — | — | US | disclosed |
| EP-2839004-B1 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION | NOGRA PHARMA LTD (IE) | 2019-06-12 | — | — | EP | disclosed |
| US-20190136237-A1 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION | NOGRA PHARMA LIMITED (IE) | 2019-05-09 | — | — | US | disclosed |
| US-20190100758-A1 | Methods of Treating Colorectal Cancer | NOGRA PHARMA LTD (IE) | 2019-04-04 | — | — | US | disclosed |
| US-10081809-B2 | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation | UNIVERSITY OF MIAMI (US) | 2018-09-25 | — | — | US | disclosed |
| US-10006029-B2 | Methods of treating colorectal cancer | NOGRA PHARMA LIMITED (IE) | 2018-06-26 | — | — | US | disclosed |
| EP-2970419-B1 | METHODS OF TREATING COLORECTAL CANCER | NOGRA PHARMA LTD (IE) | 2018-05-09 | — | — | EP | disclosed |
| CN-107252492-A | The method survived after treatment diabetes and/or promotion pancreatic islets transplantation | 诺格尔制药有限公司 | 2017-10-17 | — | — | CN | disclosed |
| CN-104487574-B | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation | 诺格尔制药有限公司 | 2017-07-07 | — | — | CN | disclosed |
| EP-2970419-A1 | METHODS OF TREATING COLORECTAL CANCER | Nogra Pharma Limited (IE) | 2016-01-20 | — | — | EP | disclosed |
| US-20150315573-A1 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION | UNIVERSITY OF MIAMI (US) | 2015-11-05 | — | — | US | disclosed |
| EP-2839004-A1 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION | Nogra Pharma Limited (IE) | 2015-02-25 | — | — | EP | disclosed |
| US-20140271860-A1 | Methods of Treating Colorectal Cancer | NOGRA PHARMA LIMITED (IE) | 2014-09-18 | — | — | US | disclosed |
| WO-2014140333-A1 | METHODS OF TREATING COLORECTAL CANCER | NOGRA PHARMA LIMITED (IE) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013158868-A1 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION | NOGRA PHARMA LIMITED (IE) | 2013-10-24 | — | — | WO | disclosed |