Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 2/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27592196 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27939066 | 0.74 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2CCNCCDK8 | |
| SCHEMBL14270262 | 0.73 | HRH1 (0.52) | ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL15526283 | 0.72 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2CCNCCDK8 | |
| SCHEMBL13097030 | 0.72 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2CCNCCDK8 | |
| SCHEMBL15526376 | 0.72 | HRH1 (0.50) | KDM4EALDH1A1SMN1; SMN2CCNCCDK8 | |
| SCHEMBL539420 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2SREBF2LMNA | |
| SCHEMBL13097029 | 0.69 | KDM4E (0.36) | KDM4EALDH1A1SMN1; SMN2CCNCCDK8 | |
| SCHEMBL2170011 | 0.69 | HRH1 (0.46) | KDM4EALDH1A1SMN1; SMN2CCNCCDK8 | |
| SCHEMBL10264193 | 0.69 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2SREBF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788336-A1 | BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | Gilead Sciences, Inc. (US) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013159064-A1 | BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES, INC. (US) | 2013-10-24 | — | — | WO | disclosed |