Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 19/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553236 | 1.00 | PDK2 (0.45) | PDK2THRBTDP1 | |
| SCHEMBL1553055 | 1.00 | PDK2 (0.45) | PDK2THRBTDP1 | |
| SCHEMBL14681786 | 0.91 | PDK2 (0.47) | PDK2 | |
| SCHEMBL10039377 | 0.91 | PDK2 (0.47) | PDK2 | |
| SCHEMBL31025647 | 0.91 | PDK2 (0.37) | PDK2 | |
| SCHEMBL4452478 | 0.91 | PDK2 (0.37) | PDK2 | |
| SCHEMBL8984635 | 0.85 | PDK2 (0.38) | PDK2THRBTDP1 | |
| SCHEMBL134285 | 0.85 | PDK2 (0.58) | PDK2THRBTDP1 | |
| SCHEMBL15041018 | 0.85 | PDK2 (0.47) | PDK2THRBTDP1 | |
| SCHEMBL29114 | 0.85 | PDK2 (0.58) | PDK2THRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060006365-A1 | Spirobifluorene derivatives, their preparation and uses thereof | COVION ORGANIC SEMICONDUCTORS GMBH (DE) | 2006-01-12 | — | — | US | claimed |
| US-8188462-B2 | Spirobifluorene derivatives, their preparation and uses thereof | MERCK PATENT GMBH (DE) | 2012-05-29 | — | — | US | disclosed |
| EP-1534661-B1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | MERCK PATENT GMBH (DE) | 2011-04-27 | — | — | EP | disclosed |
| US-20090302274-A1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | MERCK PATENT GMBH (DE) | 2009-12-10 | — | — | US | disclosed |
| US-7557249-B2 | Spirobifluorene derivatives, their preparation and uses thereof | MERCK PATENT GMBH (DE) | 2009-07-07 | — | — | US | disclosed |
| US-20060006365-A1 | Spirobifluorene derivatives, their preparation and uses thereof | COVION ORGANIC SEMICONDUCTORS GMBH (DE) | 2006-01-12 | — | — | US | disclosed |
| EP-1534661-A1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | Covion Organic Semiconductors GmbH (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004013080-A1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | COVION ORGANIC SEMICONDUCTORS GMBH (DE) | 2004-02-12 | — | — | WO | disclosed |