Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.87 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.87 |
| ▸ | MTOR | P42345 | 1/20 | 0.87 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.87 |
| ▸ | PRKDC | P78527 | 1/20 | 0.87 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.87 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.87 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.87 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.87 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 12/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.55 |
| ▸ | RAF1 | P04049 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942650 | 0.95 | PIK3CA (0.81) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL31060723 | 0.93 | PIK3CA (1.00) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL6941915 | 0.93 | PIK3CA (1.00) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL6944351 | 0.93 | PIK3CA (1.00) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL8076972 | 0.93 | PIK3CA (1.00) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL12708863 | 0.93 | PIK3CA (0.80) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL15071027 | 0.91 | PIK3CA (0.82) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL6940188 | 0.90 | PIK3CA (0.88) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL593779 | 0.90 | PIK3CA (0.85) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL593778 | 0.90 | PIK3CA (0.85) | PIK3CAPIK3CBMTORPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951724-B1 | FUSED BICYCLIC mTOR INHIBITORS | OSI PHARM INC (US) | 2011-04-27 | — | — | EP | claimed |