Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168019 | 0.87 | NAMPT (1.00) | NAMPT | |
| SCHEMBL15530100 | 0.84 | NAMPT (0.71) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL22392285 | 0.83 | NAMPT (0.75) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL163163 | 0.83 | NAMPT (0.74) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL10290830 | 0.83 | POLB (0.71) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL15530415 | 0.82 | NAMPT (0.77) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL15531263 | 0.80 | NAMPT (0.67) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL15530182 | 0.78 | NAMPT (0.65) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL15530502 | 0.77 | NAMPT (0.77) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL15531319 | 0.77 | NAMPT (0.74) | NAMPTPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013170191-A1 | METHODS OF USING ANTAGONISTS OF NAD BIOSYNTHESIS FROM NICOTINAMIDE | GENENTECH, INC. (US) | 2013-11-14 | — | — | WO | disclosed |