Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 12/20 | 0.72 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491795 | 0.89 | RXFP1 (0.88) | RXFP1KCNK3KCNK9CYP1A2CYP3A4 | |
| SCHEMBL15528928 | 0.84 | RXFP1 (1.00) | RXFP1 | |
| SCHEMBL15528441 | 0.84 | RXFP1 (0.79) | RXFP1KCNK3KCNK9CYP1A2CYP3A4 | |
| SCHEMBL15528979 | 0.83 | RXFP1 (0.78) | RXFP1KCNK3KCNK9CYP1A2CYP3A4 | |
| SCHEMBL15528871 | 0.82 | RXFP1 (1.00) | RXFP1 | |
| SCHEMBL15529586 | 0.79 | RXFP1 (0.90) | RXFP1KCNK3KCNK9CYP1A2CYP3A4 | |
| SCHEMBL17664206 | 0.78 | RXFP1 (0.74) | RXFP1KCNK3KCNK9MAPT | |
| SCHEMBL15529016 | 0.78 | RXFP1 (1.00) | RXFP1 | |
| SCHEMBL2699662 | 0.78 | RXFP1 (0.69) | RXFP1CYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL3768908 | 0.78 | MAPT (0.72) | RXFP1KCNK3KCNK9HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844345-A1 | MODULATORS OF THE RELAXIN RECEPTOR 1 | The United States of America, as Represented by The Secretary, Department of Health and Human Services (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013165606-A1 | MODULATORS OF THE RELAXIN RECEPTOR 1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-11-07 | — | — | WO | disclosed |