Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 15/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15542542 | 0.82 | CMA1 (0.66) | CMA1 | |
| SCHEMBL16704114 | 0.82 | CMA1 (0.64) | CMA1ALDH1A1MAPT | |
| SCHEMBL16736501 | 0.82 | CMA1 (0.75) | CMA1 | |
| SCHEMBL15532302 | 0.81 | CMA1 (0.47) | CMA1 | |
| SCHEMBL15544436 | 0.81 | CMA1 (0.53) | CMA1KDM4EALDH1A1MAPT | |
| SCHEMBL17644424 | 0.81 | HDAC1 (0.52) | CMA1KDM4E | |
| SCHEMBL15531941 | 0.80 | CMA1 (0.54) | CMA1HPGDKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL15532103 | 0.80 | CMA1 (0.46) | CMA1 | |
| SCHEMBL15544051 | 0.79 | CMA1 (0.56) | CMA1 | |
| SCHEMBL16736657 | 0.79 | CMA1 (0.77) | CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3045456-B1 | BICYCLIC SUBSTITUTED URACILS AND THEIR USE | Bayer Pharma AG (DE) | 2017-10-25 | — | — | EP | disclosed |
| EP-3045456-A1 | BICYCLIC SUBSTITUTED URACILS AND THEIR USE | Bayer Pharma Aktiengesellschaft (DE) | 2016-07-20 | — | — | EP | disclosed |
| EP-2847190-B1 | BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF | Bayer Pharma AG (DE) | 2016-04-06 | — | — | EP | disclosed |
| EP-2847190-A1 | BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013167495-A1 | BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2013-11-14 | — | — | WO | disclosed |