Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydroxyzine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.95 |
| ▸ | DRD3 | P35462 | 5/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.95 |
| ▸ | USP2 | O75604 | 3/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.95 |
| ▸ | DRD2 | P14416 | 3/20 | 0.95 |
| ▸ | HRH2 | P25021 | 2/20 | 0.95 |
| ▸ | HTR2A | P28223 | 2/20 | 0.95 |
| ▸ | HTR2B | P41595 | 2/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.95 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.95 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.95 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.95 |
| ▸ | DRD4 | P21917 | 1/20 | 0.95 |
| ▸ | HTR7 | P34969 | 1/20 | 0.95 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.95 |
| ▸ | HTR5A | P47898 | 1/20 | 0.95 |
| ▸ | HTR6 | P50406 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyzine SCHEMBL41449 | 1.00 | DRD3 (0.95) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Hydroxyzine SCHEMBL4492 | 0.98 | DRD3 (1.00) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Hydroxyzine SCHEMBL4491 | 0.98 | DRD3 (1.00) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Hydroxyzine SCHEMBL383277 | 0.98 | DRD3 (1.00) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Hydroxyzine SCHEMBL3061159 | 0.98 | DRD3 (1.00) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Etodroxizine SCHEMBL668191 | 0.96 | DRD3 (0.98) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Etodroxizine SCHEMBL9064076 | 0.96 | DRD3 (0.98) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Hydroxyzine SCHEMBL41450 | 0.96 | DRD3 (0.98) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Hydroxyzine SCHEMBL41448 | 0.96 | DRD3 (0.98) | DRD3HRH1CYP2D6USP2KCNH2 | |
| Hydroxyzine SCHEMBL491323 | 0.96 | DRD3 (0.98) | DRD3HRH1CYP2D6USP2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846788-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | Akron Molecules AG (AT) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013167743-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | AKRON MOLECULES GMBH (AT) | 2013-11-14 | — | — | WO | disclosed |