Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553392 | 0.82 | PIK3CD (0.48) | — | |
| SCHEMBL1553271 | 0.81 | CDK8 (0.42) | KMT2AKDM4EMAPTCDK8 | |
| SCHEMBL1505706 | 0.80 | KDM4E (0.43) | CYP2C9CYP2C19POLBTSHRNPSR1 | |
| SCHEMBL1505581 | 0.80 | KDM4E (0.43) | CYP2C9CYP2C19NAMPTKMT2AGAA | |
| SCHEMBL1505602 | 0.79 | KDM4E (0.42) | CYP2C9CYP2C19NAMPTKMT2AGAA | |
| SCHEMBL13299066 | 0.77 | PIK3CA (0.49) | — | |
| SCHEMBL1552585 | 0.76 | ABL1 (0.45) | CYP2C9CYP2C19 | |
| SCHEMBL1553500 | 0.76 | — | — | |
| SCHEMBL1553061 | 0.76 | ABL1 (0.47) | — | |
| SCHEMBL1505580 | 0.75 | CYP2C9 (0.43) | CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102199-B1 | ANTIBACTERIAL POLYCYCLIC UREA COMPOUNDS | ASTRAZENECA AB (SE) | 2011-04-27 | — | — | EP | disclosed |