Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7926347 | 0.79 | ADORA1 (0.48) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL29727928 | 0.78 | KMT2A (0.53) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL2160239 | 0.78 | KMT2A (0.53) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL30445560 | 0.76 | ADORA1 (0.46) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL12525866 | 0.76 | ADORA1 (0.46) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL11963235 | 0.76 | KDM4E (0.38) | ADORA1ADORA2AKMT2AKDM4E | |
| SCHEMBL10884409 | 0.76 | KMT2A (0.46) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL22239632 | 0.74 | ADORA1 (0.44) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL13119660 | 0.73 | ADORA1 (0.43) | ADORA1ADORA2AKMT2AGAAKDM4E | |
| SCHEMBL18864005 | 0.72 | ADORA1 (0.46) | ADORA1ADORA2AKMT2AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524706-B2 | 1,4-diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2013-09-03 | — | — | US | disclosed |
| EP-1709052-B1 | DERIVATIVES OF 1,4-DIAZABICYCLO 3.2.1OCTANECARBOXAMIDE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2011-04-27 | — | — | EP | disclosed |
| US-7589201-B2 | Derivatives of 1,4-diazabicyclo[3.2.1]octanecarboxamide, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-09-15 | — | — | US | disclosed |
| EP-1575960-B1 | 1,4-DIAZABICYCLO 3.2.2 NONANECARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2009-03-18 | — | — | EP | disclosed |
| US-20090054416-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide Derivatives, Preparation and Therapeutic Use Thereof | SANOFI-AVENTIS (FR) | 2009-02-26 | — | — | US | disclosed |
| US-7456171-B2 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-11-25 | — | — | US | disclosed |
| US-20070155749-A1 | DERIVATIVES OF 1,4-DIAZABICYCLO[3.2.1]OCTANECARBOXAMIDE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-07-05 | — | — | US | disclosed |
| US-20050182062-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054416-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide Derivatives, Preparation and Therapeutic Use Thereof | CNR1, CNR2, CACNA1A | ADORA1 35/4885ADORA2A 45/4885KMT2A 2216/4885 |
| US-20050182062-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | CNR1, CNR2, CBR3 | ADORA1 121/4885ADORA2A 246/4885KMT2A 1887/4885 |
| US-20070155749-A1 | DERIVATIVES OF 1,4-DIAZABICYCLO[3.2.1]OCTANECARBOXAMIDE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | CNR1, CNR2, NPY1R | ADORA1 67/4885ADORA2A 204/4885KMT2A 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.