Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.58 |
| ▸ | SCN1A | P35498 | 2/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.56 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15536789 | 0.89 | SCN9A (0.66) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL16448660 | 0.89 | SCN9A (0.72) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL15536887 | 0.88 | SCN9A (0.73) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL16448649 | 0.88 | SCN9A (0.59) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL15536308 | 0.88 | SCN9A (0.59) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL15536317 | 0.86 | SCN9A (0.54) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL19064812 | 0.85 | SCN9A (0.74) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL15535560 | 0.85 | SCN9A (0.67) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL15536762 | 0.85 | SCN9A (0.74) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL15536395 | 0.83 | SCN9A (0.72) | SCN9ASCN1ASCN5ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |