Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533237 | 0.94 | USP2 (0.48) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15378972 | 0.89 | USP2 (0.51) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15379420 | 0.87 | PTPN2 (0.59) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15378647 | 0.85 | HSD17B10 (0.55) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15379873 | 0.83 | USP2 (0.47) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15380459 | 0.83 | USP2 (0.47) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15379165 | 0.83 | PTPN2 (0.56) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15379162 | 0.83 | PTPN2 (0.56) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL15379667 | 0.83 | PTPN1 (0.59) | USP2ALOX15SMN1; SMN2HSD17B10RIPK1 | |
| SCHEMBL15380035 | 0.82 | USP2 (0.49) | USP2ALOX15SMN1; SMN2HSD17B10TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2847181-A1 | PYRIDAZINE AND PYRIDINE DERIVATIVES AS NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013170115-A1 | PYRIDAZINE AND PYRIDINE DERIVATIVES AS NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |