SCHEMBL15536730

SCHEMBL15536730

CC1(F)CCC(COc2cc(F)c(C(=O)NS(=O)(=O)N3CCC3)cc2C2CC2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 1.00
SCN5A Q14524 2/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16448691 1.00 SCN9A (1.00) SCN9ASCN5A
SCHEMBL16448692 1.00 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15536381 0.94 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15536832 0.93 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15536676 0.91 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15536434 0.91 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15535900 0.90 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15547326 0.90 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15536861 0.90 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15548273 0.89 SCN9A (1.00) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855428-A1 N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN Genentech, Inc. (US) 2015-04-08 EP disclosed
US-8952169-B2 N-substituted benzamides and methods of use thereof XENON PHARMACEUTICALS INC. (CA) 2015-02-10 US disclosed
US-8952169-B2 N-substituted benzamides and methods of use thereof XENON PHARMACEUTICALS INC. (CA) 2015-02-10 US disclosed
WO-2013177224-A1 N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN GENENTECH, INC. (US) 2013-11-28 WO disclosed