Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.80 |
| ▸ | SCN1A | P35498 | 2/20 | 0.80 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.80 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.80 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15536855 | 1.00 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL16449081 | 0.91 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL15549224 | 0.91 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL16448650 | 0.90 | SCN9A (0.84) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL19389033 | 0.89 | SCN9A (0.86) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL15550455 | 0.89 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL15536031 | 0.88 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL16449060 | 0.86 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL16448600 | 0.86 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL15537080 | 0.84 | SCN9A (1.00) | SCN9ASCN5ASCN1ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |