SCHEMBL15536896

SCHEMBL15536896

O=C(O)c1cc(Cl)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.72
SCN5A Q14524 6/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15536898 0.91 SCN9A (0.69) SCN9ASCN5A
SCHEMBL16448635 0.86 SCN9A (0.68) SCN9ASCN5A
SCHEMBL15535901 0.85 SCN9A (0.73) SCN9ASCN5A
SCHEMBL15536213 0.84 SCN9A (1.00) SCN9ASCN5A
SCHEMBL15535772 0.82 SCN9A (1.00) SCN9ASCN5A
SCHEMBL19429998 0.82 SCN9A (0.72) SCN9ASCN5A
SCHEMBL19429994 0.81 SCN9A (0.71) SCN9ASCN5A
SCHEMBL15536123 0.80 SCN9A (0.59) SCN9ASCN5A
SCHEMBL19411522 0.80 SCN9A (0.58) SCN9ASCN5A
SCHEMBL17422994 0.80 SCN9A (0.67) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855428-A1 N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN Genentech, Inc. (US) 2015-04-08 EP disclosed
WO-2013177224-A1 N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN GENENTECH, INC. (US) 2013-11-28 WO disclosed