SCHEMBL15539158

O=C(NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(S(=O)(=O)C(F)(F)F)c1)c1ccc(N2CCN(CC3=C(c4ccc(Cl)cc4)CCC4(CC4)C3)CC2)cc1

nearest known ligand 0.89

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	BCL2L1	Q07817	18/20	0.89

▸	BCL2	P10415	16/20	0.89

▸	BCL2L2	Q92843	2/20	0.89

▸	BAD	Q92934	2/20	0.89

▸	BCL2L11	O43521	1/20	0.89

▸	CYP2C9	P11712	1/20	0.89

▸	MCL1	Q07820	1/20	0.89

▸	ASPH	Q12797	1/20	0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL15539159	1.00	BCL2L1 (0.89)	BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL15605627	0.98	BCL2L1 (0.88)	BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL15605643	0.98	BCL2L1 (0.88)	BCL2L1BCL2BCL2L2BADBCL2L11
Navitoclax SCHEMBL522847	0.94	BCL2L1 (1.00)	BCL2L1BCL2BCL2L2BADBCL2L11
Navitoclax SCHEMBL29363785	0.94	BCL2L1 (1.00)	BCL2L1BCL2BCL2L2BADBCL2L11
Navitoclax SCHEMBL15005512	0.94	BCL2L1 (1.00)	BCL2L1BCL2BCL2L2BADBCL2L11
Navitoclax SCHEMBL30255921	0.94	BCL2L1 (1.00)	BCL2L1BCL2BCL2L2BADBCL2L11
Navitoclax SCHEMBL10316178	0.94	BCL2L1 (1.00)	BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL15540168	0.93	BCL2L1 (0.87)	BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL22325120	0.93	BCL2L1 (0.90)	BCL2L1BCL2BCL2L2BADBCL2L11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2013185202-A1	APOPTOSIS INDUCERS	BETA PHARMA CANADA INC (CA)	2013-12-19	—	—	WO	claimed
WO-2013185202-A1	APOPTOSIS INDUCERS	BETA PHARMA CANADA INC (CA)	2013-12-19	—	—	WO	disclosed
WO-2013185202-A1	APOPTOSIS INDUCERS	BETA PHARMA CANADA INC (CA)	2013-12-19	—	—	WO	disclosed